|
|
DOI Prefix 10.20431 |
Information
Journal Policies
Synthesis of Benzimidazole Derivatives Containing Schiff Base Exhibiting Antimicrobial Activities
Alam S.A.M.F.1,Ahmad T.2, Nazmuzzaman M.2,Rahman S.3,Ray S.K.2,Sharifuzzaman M.4, Karim M.R.4,Alam M.G.5,Ajam M.M.2,Maitra P.2,Mandol D.6,Uddin M.E.7, Ahammed T.5
2.Dept. of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh
3.Dept. of Biology and Chemistry, North South University, Dhaka, Bangladesh
4.Dept. of Microbiology, Chittagong University, Chittagong, Bangladesh
5.Dept. of Microbiology, Gono Bishwabidyalay, Dhaka, Bangladesh
6.Dept. of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh
7.Dept. of Biochemistry and Molecular Biology, Gono Bishwabidyalay, Dhaka, Bangladesh
Citation :Alam S.A.M.F.,et.al, Synthesis of Benzimidazole Derivatives Containing Schiff Base Exhibiting Antimicrobial Activities International Journal of Research Studies in Biosciences 2017,5(7) : 18-24
A series of 2-substituted Benzimidazole having imine linkage were synthesized by two step reactions. In the first step, o-phenylenediamine was condensed with p-amino benzoic acid in xylene and poly phosphoric acid to give 2-amino Benzimidazole. In the second step, 2-amino Benzimidazole is treated with different substituted aldehydes and ketones to form substituted Benzimidazole having imine linkage. The synthesized compounds were evaluated for anti-bacterial activity against Staphylococcus aureus and Escherichia coli by tube dilution method. The compounds SAM-2 and SAM-10 were found to be more potent than standard drug vancomycin against Gram (+) ve and Gram (-) ve bacteria. The compounds SAM-4 and SAM-9 had anti-microbial activity comparable to standard drugs against both the microorganisms. The aims of this study to synthesize novel benzimidazole derivatives containing Schiff's base and evaluate the antimicrobial activity of the synthesized derivatives against S. aureus and E. coli