Humans by nature make efforts to cope with climate variability and change, however, adaptation to climate change manifest in varied ways and forms. From an ethnic and gender perspective, this study examined the choice of livelihood coping strategies in the face of climate variability in the Kasena- Nankana Municipality and the Bongo District in the Upper East Region of Ghana. The concurrent mixed method approach was used.Hence, both qualitative and quantitative data collection and inference techniques were combined. A sample size of 312 rural farmers (194 males and 118 females; age range of 18-73 years), were involved in the study. Two Focus Group Discussions (between 8 to 12 members each) were conducted in each community. The Chi-square test revealed that, coping strategies such as planting of trees and shrubs on farmlands, growing different varieties of crops, collecting and storing grass during the rainy season, among others had very significant relationships with ethnicity, with P Values of less than .001 (P< .001).Gender however, didn't have a significant relationship with coping strategies adopted as P-Values for all coping strategies except collecting and storing of grasses during the rainy season (x2=4.41, p=0.04) were greater than the significance level of 0.05.