The main objective of the study was to investigate the relationship of Socio-economic Status (SES) with Depression of Senior Citizens Living in Himachal Pradesh and Uttar Pradesh State of India. 2000 sample were selected on the bases of simple random method viz: 1000 of each State. 500 male and 500 female gender wise categories were selected of each state. The study was conducted by using the Standardized Questionnaire for measuring the Depression level of Senior Citizens of both states i.e.: Zung Self-Rating Depression Scale (SDS). The data collected was statistically analyzed by using Percentage and Chi Square was specially used to find out the significance difference in between Socio-economic Status (SES) & Depression Level of Senior Citizens. On the basis of statistical analysis it can be briefly concluded that senior citizens of Himachal Pradesh and Uttar Pradesh state differed significantly in respect to their Socio-economic Status with Depression Level.