Islam and Muslims were and still are subject to systematic attacks on their physical beings and on their religious belief. These attacks are from individual persons, and from organized institutions as well; who are fiercely attacking the Islamic Religion, to disgrace the Islamic Values and distort the image of the Prophet Mohammed-peace be upon him. This paper is an attempt to shoulder the reasonability to speak to these people in their own languages to correct some wrong images; they had about Islamic Faith. On the other hand we want to defend Muslim entities and individuals as well. The paper discusses some questionable approaches used by the Orientalists in translating the Holy Quran. It will shed light on mistakes made in these translations. The findings proved that there was great harm-intentionally or unintentionally-made to Islam and Muslims due to these mistranslation practices of the Quran, the Holy Book of Muslims and the ultimate authentic reference to all Islamic laws and Islamic Teachings.