Plant breeding has to be considered one of the longest and continuous activities conducted by human for improvement of crops for different trait, drought stress tolerance crop breeding is one of human breeding objective and it is one of the major yield constraints for different type of crops. Traditionally for developing drought tolerant cultivars conventional based selection is practiced. Although this approach is effective for several years but conventional methods are time consuming and labour intensive. Biotechnology tool such as Identification of drought related quantitative trait loci (QTLs) coupled with marker assisted selection, Transgenic and "omics" technologies promise to make progress in breeding for drought tolerance through a more fundamental understanding of underlying mechanisms of drought tolerance and identifying potential candidate genes so in these review cover both conventional and modern biotechnology tool that are used for drought tolerance crop improvement and the new approaches provide opportunities to direct the continued breeding of genotypes giving stable yields under drought stress.