Background: Though Blood transfusion remedy is well known it is not without risks and may lead to the transmissions of infectious agents from donor to recipient. Screening of the common transfusiontransmissible infections (TTI)of donors blood is mandatory to regulate the safety of blood transfusion. So the aim of this study is to detect the prevalence of TTI from donated blood at a Hawassa regional blood bankscenter.

Methods: This was a retrospective, descriptive study. All blood donors' records from January 2014 to December 2015 were included; we analyzed 6849 blood donors document and the differences in prevalence of TTI, gender, age, occupation and type of donation the collected data were entered into SPSS version 20.0 Logistic regression analyses was performed to identify the influencing factors.

Results: The overall prevalence of TTIs is 5.78% of which HIV, HBV, HCV, and syphilis account for 1.3%, 3.4%, 0.7%, and 0.4% respectively. Syphilis and HIIV increased with age also showed higher prevalence among family donation (1.7% and 1.2% respectively). The rate of HBV was higher among donors with the age groups 35-44 (P< 0.001), and age group 45-54 (P=0.001). On the same way HCV increased across age groups 35-44 (P=0.001), age group 45-55 (P= 0.025). Again higher among Volunteer donors (P < 0.007).

Conclusion: lower rate of TTI was reported compared with most of previously conducted studies as well as to the general population of Ethiopia. To accomplish more the responsible body should teach the community about the blood-borne transmittable infection and voluntary donation should be encouraged by vigorous lessons in order to diminish transfusion-related infections. Simultaneously the country should work hard in introduction of more sensitive screening methods to detect TTIs earlier and thus reduce the risks associated with window periods.