Bovine brucellosis is a worldwide zoonotic disease of animals and humans which result socioeconomic impacts on the worldwide. It is caused by various species of genus Brucella. Primarily brucellosis is disease of animals however human also susceptible for the disease which result more than 500,000 cases of human per year all around the world. The disease is transmitted by ingestion of Brucella induced feed, consumption of dairy products from infected animals, close contact with infected animal as well as respiratory aerosols between animals. Human acquire the disease by consumption of raw dairy products, close contact with infected animals and through respiratory rout. In animals the clinical signs are related to reproductive systems. In pregnant cows it cause Retained placenta, metritis and the most common sign in Brucella infected cow is Abortions, which is occur after the fifth month of gestation. In bulls it is characterized by Orchitis, epididymitis and Vasculitis. Various methods are employed for the diagnosis of brucellosis including rose Bengal test, complement fixation test (CFT), bacterial culture and milk ring test. Among Serological tests, rose Bengal tests are used to screen animals however CFT is used to confirm the causative agent. The bacillus can be isolated by bacterial culture on Brucella selective media. In developed countries Brucellosis was successfully eradicated by using test and slaughter method of control. However this method of control is not employed in developing countries because of economic aspect of the countries. In developing countries other methods such as immunization of animals, farm sanitation and community awareness were applied to reduce the spread of disease.