This study evaluated the Synergistic efficacy of tissue extracts of Alstonia boonei and Vitex grandifolia against some common bacteria pathogens. Both plants were obtained from freshwater swamp in Wilberforce Island, Nigeria. Water, ethanol, methanol and hexane were used to extract the dried plant materials in a ratio of 1:1. Agar well diffusion technique was employed for the sensitivity testing. The results revealed that ethanolic extracts had superior zone of inhibition on the overall. The highest zone of inhibition for synergistic potency of the ethanolic extracts were 13.00mm (Bacillus sp) in root + leaf, 15.00 mm (S. aureus) in root + leaf, 13.00 mm (P. aeruginosa) in stem + leaf, 14.00 mm (Proteus sp) in stem + leaf, and 15.00mm (Salmonella sp) in root + leaf. There was significant variations (P< 0.05) in the zone of inhibition that was achieved for each of the bacterium under study and plant parts. The synergistic results of two or more parts of the plant combinations were superior as compared to the individual tissue extracts. The antimicrobial activities of the synergy of Alstonia boonei and Vitex grandifolia tissues suggests that it can be used as broad spectrum antibiotics.