A cross sectional study was conducted from May 2016 to February 2017 with the objective of estimating the prevalence of mange mites' infestations on small ruminants and identifying the potential risk factors and major species of mites in Kindo Koysha District, Wolaita zone, Southern Ethiopia. A total of 384 small ruminants randomly selected, of which 154 sheep and 230 goats were examined for the presence of mange mites, from which 7(4.55%) and 23 (10.0%) sheep and goats were found positive respectively. The overall prevalence of both species was 7.81%( n=30). The genera of mange mites identified with the study were Demodex 8(2.08%) and Sarcoptes 20(5.2%), and mixed infection 2(0.52%), of these; the genus Sarcoptes was more prevalent in the study area. It was observed that the prevalence of mange mites infestation was significantly higher in small ruminants with poor body condition score (p< 0.05). But age, sex, species of animals, season of a year and agro-ecology were not affected the prevalence of mange mites of small ruminants.