Litopenaeus vannamei (shrimp) farming is playing a pivotal role in the socio-economic development of India. India is exporting 4.4 lakh tones of shrimp products (2016-17) of which vannamei share is 3.30 lakh tonnes. The Andhra Pradesh state is the largest vannamei producer amongst the shrimp farming states of India contributing 2.31 lakh tonnes (70% of total Indian exports). A study was undertaken during 2014-15 in Prakasam district of Andhra Pradesh, to analyze the constraints prevailed in L.vannamei culture. The Prakasam district has 3 revenue divisions and 56 Mandals (Taluka's) with 2,273.39 ha brackish water area is under shrimp culture. The study area was selected purposively and the respondents were identified using simple random technique. The sample size for the current investigation was 60. The study was conducted based on personal interview schedule aided with well structured and pre-tested questionnaire consisting of 11 items of constraints such as seed, feed, diseases, management aspects, inputs, harvest, labour related, extension activities, infrastructure, marketing and miscellaneous constraints. Garrett's ranking technique was employed for allotment of ranking to the various constraints. The data was analyzed using frequency and percentages. The results showed that out of the total farmer's surveyed, input constraint (rank- 1) was opted as the major constraint, followed by other constraints such as lack of marketing (rank-2), infrastructure constraint (rank-3), Seed constraint (rank-4), management constraint (rank-5), Miscellaneous constraint (rank-6), disease constraint (rank-7), Feed constraint (rank-8), harvest constraints (rank-9), extension constraint (rank-10) and labour constraint (rank-11). The results were reflecting the existing scenario of L.vannamei culture in the study area. Irrespective of the ranking of the various constraints, majority of the constraints were the reasons behind the setback of vannamei crop failure. The study conclude that the regulating agencies such as MPEDA of GOI to take appropriate remedial measures to combat the identified constraints of the present study.