The high incidence of diabetes and widespread use of the pesticide, dichlorvos (DDVP) make their co-occurrence plausible in the general population. This study was therefore, undertaken to investigate effects of dichlorvos exposure on lipid homeostasis, oxidative status and hepato-renal functions in streptozotocin-induced diabetic rats. DDVP was orally administered at 8 mg/kg bw (1/10th LD50) to both normal and diabetic rats. Exposure to the organophosphate caused an aggravation of the hypertriglycridemic outcome in diabetic rats while also increasing their phospholipid contents. Induced diabetes lowered HDL-C concentration, while increasing the LDL and VLDL contents. DDVP enhanced concentration of the triglyderide-rich lipoprotein, VLDL in the diabetic animals. DDVP exposure and STZ-induced diabetes reduced HMG CoA reductase activity, however, their co-occurrence brought about a stimulation of the enzyme. Lipid hydroperoxides level was highest in DDVP-exposed diabetic rats while plasma total antioxidant capacity was drastically reduced. Moreover, DDVP escalated production of advanced oxidized protein products in diabetic rats. Pronounced nephrotoxic effects were observed in dichlorvos-exposeddiabetic rats, evidenced by increased blood urea and creatinine. Similarly, activities of plasma transaminases, AST and ALT, markers of hepatic damage were markedly elevated.The findings of this study imply that DDVP has the tendency to exacerbate complications associated with diabetes.