Moringa oleifera (M. oleifera) is, native of the Indian subcontinent, plant of angiosperm utilized in food and medicine. It is cultivated in all tropical and sub-tropical regions of the world. The therapeutic prophylactic and nutritional uses of this plant are extensively used. Moringa oleifera is an edible plant. A wide variety of nutritional and medicinal virtues have been attributed to its roots, bark, leaves, flowers, fruits, and seed. Phytochemical analyses have shown that its leaves are particularly rich in potassium, calcium, phosphorous, iron, vitamins A and D, essential amino acids, as well as such known antioxidants such as β-carotene, vitamin C, and flavonoids . Various therapeutic methods used in treatment of atherosclerosis but fail to prevent complication of cardiovascular origin ,so we used medicinal plant in therapy for excluding complication.Moringa oleifera is used as hypocholesterolaemic effect in Sprague dawley rats as shown in recent studies.However ,we need more data about scientific uses of this natural product.The aim of the present study was to evaluate the effect of aqueous extract of moringa oleifera leaves on Lipid profile; triglycerides (TGs), cholesterol, high density lipoproteins (HDL) and low density lipoproteins (LDL) and very low density lipoprotein (VLDL),as well as on liver tissues for superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA),Total antioxidant capacity (TAC),and gene expression for LDLgene.The extract was administered at two doses,200mg/kg bw and 300mg/kg bw respectively orally for a period of 30days.Tamoxifen with a dose of 0.5 mg/ kg b.wt.by S/C for 5consequtive days induced atherosclerotic rats showed hyperlipidemia ,hypercholesterolemia,loweing in TAC,SOD,and MDA,while increase the catalase ratio.Moringa groups showed cure most of the deviation near to the normal ratio.The present study reveals that moringa oleifera extract possesses antiatherosclerotic and antihyperlipedemic effect in atherosclerotic induced rats by tamoxifen .