The study was carried out to investigate the harmful effects of UVC radiation on skin and eye of mice. Eighty male Albino mice were used in this study. The mice were equally divided into three groups as control, UVC and recovery. UVC group mice were divided into two groups first irradiated for 1hour per day and second irradiated 2hour per day during 30 days. Autopsy samples were taken from the skin and eyes of mice in different groups and fixed in 10% formol saline for twenty four hours. The obtained tissue sections were collected on glass slides, deparaffinized and stained by hematoxylin and eosin stain for examination through the light electric microscope. The results showed that, UVC radiation has harmful effects on skin and eye of mice and the recovery was found insignificant.