The trial was conducted to evaluate fungicide efficacy for the control of Garlic rust at Holeta during 2017 and 2018 cropping season. Four type of fungicide from them three systemic:-250 gram/L propiconazole (Tilt 250EC), a mixture of Thiophanate-Methyl 310 gram/L and Epoxiconazole 187gram/L (Rex Due) and Propiconazole; one contact fungicide chlorathalonil 75% (Rova) and untreated control arranged in RCBD with three replications were used for the study. Rust was found reduce bulb weight, bulb diameter, number of cloves per bulb 55.9%, 16.33%, 33.6% respectively. Yield was found reduced significantly, Rex Duo and Propiconazole were found superior in controlling of rust and give the highest yield 1881kg/ha and 1913kg/ha in 2017 and 2018 respectively. There was up to 106% yield advantage were obtained from Rex Duo sprayed plot in 2017 and 37.8% in 2018 cropping season.There was a significant negative correlation observed between Bulb weight, bulb diameter, number of cloves per bulb and yield to that of area under diseases progress curve (AUDPC).Spraying Rex Duo twice at 21-days interval starting from the onset of the disease insured a gain of 46818.125 Ethiopian Birr (ETB) per hectare additional net benefit and maximum marginal rate of return 1440.6%.