In view of the limitations or inadequacies of sole use of organic or inorganic fertilizers, hence, there is a dire need to critically appraise the potential of combined application of organic and inorganic fertilizers as a nutrient source to improve soil fertility and ensure balanced crop nutrition. To this end, an experiment was initiated to assess the effects of integrated application of Centrosema pubescens residue and certain inorganic fertilizers on soil chemical properties and maize (Zea mays L.) performance. The experiment was carried out at the Teaching and Research Farm of the Ekiti State University, Ado - Ekiti, Nigeria, during 2015 and 2016 cropping seasons. The experiment was laid out in a randomized complete block design, with three replicates. The plant residues and inorganic fertilizers treatments included: sole Centrosema pubescens residue (SCPR); Centrosema pubescens residue (CPR)+Ammonium sulphate (AS) (CPR+AS); Centrosema pubescens residue+NPK (CPR+NPK); Centrosema pubescens residue+single superphosphate (SSP) (CPR+SSP) and no fertilizer application (NFA). The results obtained indicated existence of significant (P = 0.05) differences among the different Centrosema pubescens residue - based fertilizer combination treatments as regards their effects on soil chemical properties and maize yield. Relative to initial nutrient status of the soil before cropping, at the end of 2015 cropping season, CPR+SSP, CRP+NPK and SCPR increased soil organic carbon (SOC) by 21, 18 and 15%, respectively, contrasting decreases of 31 and 51% for CPR+AS and C, respectively. Similarly, at the end of 2016 cropping season, CPR+SSP, CRP+NPK and SCPR increased SOC by 24, 23 and 20%, respectively, contrasting decreases of 44 and 61% for CPR+AS and C, respectively. At the end of 2015 cropping season, CPR+SSP, CRP+NPK and SCPR increased total N by 19, 47 and 35%, respectively, contrasting decreases of 51 and 67% for CPR+AS and C, respectively. At the end of 2016 cropping season, CPR+SSP, CRP+NPK and SCPR increased total N by19, 47 and 35%, respectively, contrasting decreases of 51 and 67% for CPR+AS and C, respectively. Mean values of maize yield data over the two years of experimentation indicated that integrated application of Cenrosema pubescens residue and inorganic fertilizers significantly increased maize grain yield from 0.81 t ha^-1 for C to 1.70, 1.91, 2.33 and 2.10 t ha^-1 for the respective SCPR, CPR+AS, CPR+NPK and CPR+SSP.