This article assessed the influence of Product leadership on the management of efficiency levels in the pharmaceutical industry in Kenya. In research methodology, the study adopted cross sectional survey design. The population of interest was composed of registered Kenyan pharmaceutical manufacturing companies as availed by the KAM directory. Sampling technique was purposively sampling. The research instrument was a questionnaire. Analysis of the data was done using (SPSS). Regression and correlation analysis was done to test the relationship between the study variables. The study findings indicated that there was a positive and significant relationship between product leadership and the management of efficiency levels. The study concluded Kenyan pharmaceutical industry have put a lot effort in producing high quality generic pharmaceutical products but are trying to implement strategic management practices. The study recommends that Kenyan Pharmaceutical companies need to implement product leadership in order to manage its efficiency levels.