As a product of economic globalization and internet economy, Cross-cultural Teams (CCTs) are increasingly becoming an important organizational form of multinational corporations and multinational organizations. However, what are the motive powers of CCTs' leadership effectiveness? What is the influencing mechanism of the motive powers? What are the mediating effect and moderating effect in the above leadership process? These theoretical questions haven't been solved effectively at present. Considering the Sino -Germany CCTs as the research object and based on cross-cultural management theory and empirical method, the paper explores the mechanism how Sino-Germany CCTs leadership influences the leadership effectiveness from perspectives of influencing mode and influencing effectiveness. The conclusions of this research a re as follows: Sino-Germany CCTs leadership exercises its influence on leadership effectiveness through leadership object's cognition of leadership as intermediary variable; its process is also restricted by individual-team matching degree; in addition, leadership effectiveness is influenced by the cultural background of principal leaders in the team.