Several decades of research have shown leadership as vital to organizations. Existingstudies have found that one particularly important type of leadership that influences organizational development, growth, and competitive advantage is strategic leadership. Currently, African countries are transitioning from state-controlled to capital market structures as a result, organizations are exposed to intense competition particularly from multinational corporations taking advantage of economic liberalization programs. Strategic leadership, therefore, seems important because it is more likely to enable African organizations to integrate effectively in the global economy. The purpose of this study, therefore, is to examine leader effectiveness in African organizations, focusing on Ghanaian organizations. The researcher sampled about three hundred employees as subordinates and thirty executives (as leaders) of five organizations in Ghana. Specifically, the study defined operatives and supervisors as followers and executives as strategic leaders. As a cross-sectional study, the researcher surveyed followers and executives to report on their virtuous followership and effectiveness respectively. Existing instruments were used to measure follower expectancy, developmental stage, situational strength, and strategic leader effectiveness. However, because virtuous followership is a new concept, the researcher developed an instrument to measure it, and in addition interviewed some of the followers (n = 10) and strategic leaders (n = 5). Based on the regression results that were generated, the hypotheses stated earlier were tested.H1: Follower expectancy will influence strategic leader effectiveness: Since the follower expectancy was a positive predictor of strategic leader effectiveness, the model predicted that higher follower expectancy predicted higher strategic leader effectiveness in the context of the Ghanaian corporate environment.H2: Virtuous followership mediates the relationship between follower expectancy and strategic leader effectiveness:It was found that virtuous followership partially mediated the relationship between follower expectancy and strategic leader effectiveness