Proteins, lipids and carbohydrates in muscle and liver tissues were studied with respect to different seasons in Johniusaneus. Marked changes were observed in the biochemical composition of the muscle and liver of normal and infected fish .High protein content was observed during pre-monsoon (81.7±0.11mg/g)in normal muscle. While high lipid concentration was seen in post-monsoon (43.7+0.67mg/g) in normal liver. Whereas high concentration of carbohydrates was found in post-monsoon (3.9+0.84mg/g) in infected muscle.