Oguta Lake was the largest natural lake in Imo State, south-east Nigeria. It is used for several purposes ranging from Agriculture, domestic, industrial, artisanal fishing, transportation, and tourism, and constantly received wastes and effluents from these activities. A study of the physico-chemical parameters and heavy metal accumulation in water and sediment of Ogutalake was conducted to ascertain the effects of the anthropogenic activities on the lake between Julys to September, 2016, in order to add to the basement information on the lake. Iron concentration in water sample was only revealed to exceed NESREA recommendation standard for aquatic life, and Iron was shown has the highest concentration in the sediment. A further significant spatial variation in some physico-chemical and heavy metal accumulation across the sampled stations in the lake was observed. Erosion of the ad journey lands and run-off of sewages was found to be accounted for the changes.