The leaves of B Racemosa were collected from its natural habitat in Wukari local government area of Taraba state, Nigeria. The method of cold maceration was used in the extraction by serial exhaustive extraction method. The result obtained from antimicrobial activity obtained from the extract of the leave of. B. racemosa revealed that not all the extract of leaf of inhibited or exhibited antimicrobial activity against E. coli, Stapyllococus aureus, Salmonella spp, Candida albicans and Aspergillus niger. The result revealed that almost all of the extract exhibited or inhibited antibacterial against E. coli, Stapyllococus aureus, Salmonella spp, Candida albicans and Aspergillus niger, except extract of chloroform and acetone which did not show any inhibition on Salmonella spp (00.00 mm), extract of chloroform donnot act against Candida albicans and Aspergillus niger, extract of ethanol and ethyl acetate show zero inhibition on Aspergillus niger. Extracts that do not inhibit or exhibit antifungal activity on certain bacterial, have zero zone of inhibitory (00.00 mm).