Diarrhoea a commonest food and water born disease affecting equally from neonates to geriatrics due to varied causative pathogens, commonly presents with loose motion may be watery or varied natured stool ,principally due to altered water and electrolyte absorption as a result of altered sodium potassium ATPase pump caused by altered mechanism of normally secreted bio molecules Enkephalin.

For diarrheal disease control the common prescription these days is combination of broad spectrum anti protozoal and broad spectrum anti-bacterial ,among them are tinidazole - norfloxacin and ornidazole - ofloxacin , and tinidazole and co trimoxazole but unusual presentation observed and reported by patients or parent with ofloxacin and ornidazole consumption ,necessitate the present evaluation which affirm superiority of Tinidazole-norfloxacin and tinidazole and co trimoxazole as compared to Ofloxacin and rnidazole in both therapeutic outcome ,safety profile and drug adversity as - Ofloxacin -Ornidazole both acts on DNA and alters DNA function ,posses high volume distribution thus both emain in GIT for very short duration thus fails to ensure sustained availability to sterilize the GIT while ther anti-diarrhoeal composite Norfloxacin never binds with DNA but to DNA substrate ,posses very low volume distribution ,thus remain in GIT for comparatively longer duration ,ensure gut sterility ,Co trimoxazole inhibit dihydrofolate enzyme inhibiting synthesis of folinic acid ,posses low volume distributionand stay longer in GIT thus check post diarrheal sequel i.e- mucous colitis and Urinary tract infection.

All the three anti diarrheal combination proved safe for haematological, hepatic and renal parameter. Thus Ofloxacin-Ornidazole remain no longer choice for Diarrheal management considering its hazards and outcome.