Hypothyroidism is increasing worldwide and female predominate male i.e.- 1 out of 50 female and 1 out of 1000 male . TSH (thyroid stimulating Hormone, a secretion of pituitary gland) level is adjudged as an index of diagnosis of thyroid function. Hypothyroid status needs L thyroxin supplementation but its variable schedule poses metabolic dysfunction.

Objective of Study: To adjudge clinical effect of early morning fixed time intake of L thyroxin verses unscheduled administration in bioregulation of TSH level and metabolic process.

Material & Methods: 1000 patients presenting with features suggestive of thyroid hypo function attending at Centre For Endocrinal & Metabolic research, Aarogyam Punarjeevan, Ram Bhawan, Ara Garden ,Patna 14 and Institute of applied Endocrinology, National Institute of Health & Research, Warisaliganj (Nawada) Bihar 805130 were selected for the proposed study. For the comparative study patients were classified in two groups comprising equal number of patients and one group is administered L thyroxin early morning at fixed time as first intake while other group at varied time. Both group were recommended L thyroxin and other adjuvant as per their need.

Result: Present study of Levothyroxine supplementation at fixed schedule at early morning prior to onset of body biokinetics ensured excellent therapeutic outcome with TSH bioregulation and better quality of life and sustained and progressive therapeutic response without any adversity.

Conclusion: Early morning intake of L thyroxin at fixed time as first intake is worth practicing for optimal thyro regulation and clinical outcome.