Altered thyroid function is more common among female and hypothyroidism predominate with clinical features of Weight gain, asthenia due to declined oestrogen in female and declined testosterone in male resulting lowered BMR yielding subcutaneous accumulation of mucin and retention of water and electrolytes.

But in the present study male presenting with high TSH, low thyroxin (T4) and normal testosterone presented with body weight less than ideal body weight while person with low TSH, raised thyroxin (T4) and low testosterone presented with weight more than Ideal body weight. None was having any other pathology.

This study suggest that weight gain or weight loss is secondary to gonadal hormone oestrogen or testosterone which affect BMR and subcutaneous accumulation of mucin or loss of subcutaneous fat. Hence weight gain or weight loss is an effect of altered BMR not the thyroid hormone directly.