Psoriasis, a chronic non communicable, painful, disfiguring and disabling disease for which no cure and poses great negative impact on patients quality of life and can affect any age or sex. In the wake of commonly prescribed immunosuppressive or biologicals, in the present study self blood and betamethasone injection intramuscular administration as per suggested schedule achieved beginning of improvement in all the cases by 6th month of therapy and complete absence of manifestation in all by 42 months without any adversity or withdrawal effect, considered as neutralization of generated protein responsible for increased rate of skin cell death and increased keratinocytes.