Urolithiasis, a world wide problem rising in geometric progression is considered to be solely due to changed dietary habit, dietary constituents and life style. Recurrence even on surgical removal or lithotripsy, the only way is to ensure medical expulsion of stone and bioregulated mineral biokinetics ,assessment of indigenous herb active constituent i.e.- Carica papaya (root) and Piper nigrum (berries) extract daily orally in early morning proved worth in expelling the stone per urethra from various sites of KUB and check recurrence of urolithiasis and achieved grade I clinical cure in 97% cases without any adversity or recurrence in 5 yrs of rigrous follow up .