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DOI Prefix 10.20431 |
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Free Triiodothyronine Level Indicates the Degree of Myocardial Injury in Patients with Acute Myocardial Infarction
Dr.Lalitha.R1,Dr.G.Komala2*,Aravinth3,Dr.Priya Senthilkumar4
2.Affiliated to the Dr. M.G.R. Medical University, Senior Assistant Professor, (Presently Associate Professor, Government Vellore Medical College, Vellore), Department of Biochemistry, Govt.Kilpauk Medical College, Chennai-10
3.II MBBS student, Affiliated to the Dr. M.G.R. Medical University, Govt. Kilpauk Medical College, Chennai-10
4.Affiliated to the Dr. M.G.R. Medical University, Associate Professor, Department of Preventive and Social Medicine, Govt. Kilpauk Medical College, Chennai-10
Citation :Dr.Lalitha.R,et.al, Free Triiodothyronine Level Indicates the Degree of Myocardial Injury in Patients with Acute Myocardial Infarction International Journal of Clinical Chemistry and Laboratory Medicine 2017,3(1) : 21-28
Inflammation implicated in the pathophysiology of acute myocardial infarction causes release of cytokines which disrupt the hormonal milieu. This leads to reduced circulatory levels of hormones like Triiodothyronine which cause worsening of the pathological remodelling of cardiac myocytes. Free T3 levels are implicated as prognostic markers after MI. This cross sectional study on 88 MI patients was conducted to correlate severity of myocardial damage as assessed by TropI, WMSI and hsCRP with Free T3 levels. Results revealed a negative correlation of hsCRP, Trop I and WMSI with FT3 levels indicating that as FT3 levels decrease myocardial injury is increased, though no statistical significance could be established, medical significance to be considered. The negative correlation and trend observed with decreasing FT3 levels and increasing concentrations of hsCRP, TropI and WMSI need intervention, though limited by small sample size.