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DOI Prefix 10.20431 |
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International Journal of Clinical Chemistry and Laboratory Medicine
Volume-2 Issue-1, 2016, Page No:17-21
Elevation of Plasma Copeptin in Acute Myocardial Infarction in Pigs is Related to Changes in Mean Arterial Blood Pressure but not to Myocardial Ischemia
Anna Slagman1, Timo Jerichow2, Joachim Struck3, Jörn O. Vollert4, Dörte Mans1, Malte Schröder1, Julia Searle1, Jeanette Schulz-Menger5, Ralf Schindler6, Martin Möckel1
1.Department of Emergency Medicine, Charité University Medicine, Berlin, CVK and CCM, Germany
2.Department of Cardiology and Intensive Care, Vivantes Wenckebach-Klinikum; Berlin, Germany
3.Adrenomed AG, Hennigsdorf, Germany
4.Clinical Diagnostics Division, BRAHMS GmbH, Hennigsdorf, Germany
5.Working Group Cardiovascular MR, Department of Cardiology, HELIOS-Klinikum Berlin-Buch and Charité University Medicine, Berlin, Germany
6.Department of Nephrology and Intensive Care Medicine, Charité University Medicine, Berlin, CVK, Germany
2.Department of Cardiology and Intensive Care, Vivantes Wenckebach-Klinikum; Berlin, Germany
3.Adrenomed AG, Hennigsdorf, Germany
4.Clinical Diagnostics Division, BRAHMS GmbH, Hennigsdorf, Germany
5.Working Group Cardiovascular MR, Department of Cardiology, HELIOS-Klinikum Berlin-Buch and Charité University Medicine, Berlin, Germany
6.Department of Nephrology and Intensive Care Medicine, Charité University Medicine, Berlin, CVK, Germany
Citation : Anna Slagman,et.al, Elevation of Plasma Copeptin in Acute Myocardial Infarction in Pigs is Related to Changes in Mean Arterial Blood Pressure but not to Myocardial Ischemia International Journal of Clinical Chemistry and Laboratory Medicine. 2016;2(1):17-21.
Abstract
Background: Copeptin increases early after myocardial infarction (MI). We used a porcine MI model with serial copeptin-testing and assessment of hemodynamic variables to evaluate the trigger for copetin-release and the liberation kinetics of copeptin in MI.
Methods: AMI was induced by percutaneous transluminal coronary angioplasty (PTCA). Blood samples were taken in 30-minute intervals.
Results: All animals (n=4) had a comparable infarction size (10.02 ± 2.11% of the left ventricle) and elevated troponin T levels. Highest copeptin levels were measured 30 minutes after the beginning of ischemia with a rapid decrease at 60 minutes, while coronary occlusion was still persisting. Animals with high copeptin values showed a significant drop of MAP (37.24% and 54.20% reduction from MAP-baseline).
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