Antimicrobial activity of some medicinal plants traditionally used by local communities in the treatment of tuberculosis and other respiratory diseases was carried out. The antimicrobial activity of the plants extracts against some microbial pathogens was investigated as preliminary study to screen the plants for their anti-tuberculosis activity. The antimicrobial test was done using agar disc diffusion method and the minimum inhibitory concentration (MIC) was also determined by Micro broth dilution method. The result indicated that the extracts had varied activity against the tested organisms. The extracts also showed dose dependent antimicrobial activity but significantly lower than the standard antibiotic drugs (ciprofloxacin and Ketoconazole). The extract of E. hirta has no activity against E. coli at the tested concentrations but shown the zone of inhibition range from 10- 16mm for other tested organisms. E. hirta has MIC of 15µg/ml against K. pneumonia and C.albicans and 30mg/ml for B.subtilis, S. typhi and S aureus. The extract of C. mucronata has shown zone of inhibition range from 12- 16mm but it has no activity against B. subtilis at the tested concentrations. It has MIC of 15µg/ml against C.albicans, B. subtilis, K.pneumonia, E.coli and 30µg/ml against S. aureus. The stem bark extract of X. americana has shown the zone of inhibition range of 10-16mm and active against all the tested organisms. It has MIC of 15µg/ml against S. aureus and K. pneumonia. The leaf extract of W. indica has shown zone of inhibition ranging from 11- 16mm. It was active against all the tested pathogens and exhibited MIC of 15µg/ml against S. aureus and C. albicans. The leaf extract of P. reticulatum has shown the zone of inhibition ranges from 9-15mm against the tested organisms. It exhibited MIC of 15µg/ml against S. typhi. The aerial parts extract of S. hermonthica has shown zone of inhibition ranges from 12- 16mm. The extract has shown the zone of inhibition (12, 14 and 16mm) against C. albicans at the concentration of 15, 30 and 60 µg/ml respectively. But the extract has no activity against S. typhi at the tested concentrations. The extract has MIC of 15µg/ml against B. subtilis and C. albicans. The extract of T. indica has shown the zone of inhibition ranges from 10-15mm. But the extract has no activity against C. albicans at all tested concentrations. It has MIC of 15µg/ml against K. pneumonia and E.coli. The extract of E. senegalensis has shown the zone of inhibition ranging from 11- 14mm. However the extract has no activity at the lowest concentration of 15µg/ml against all the organisms except S. aureus. The extract has MIC of 15µg/ml against S. aureus and 30µg/ml against all other organisms tested. The leaf extract of B. paradoxum has shown a zone of inhibition of 16mm against E. coli and zone of inhibition ranges from 11- 16mm. The MIC of the extract against E. coli, S. typhi and B. subtilis is 15µg/ml and 30µg/ml for C. albicans. However the extract has no activity at all tested concentrations against S. aureus and k. pneumonia. The extracts that exhibited zones of inhibition greater than 10mm were considered active and therefore recommended for further screening to isolate and characterize the bioactive chemical constituents.