The 21^st century idea of "green chemistry" is gradually changing the modern scientific research towards the use of sustainable, safe and benign solvents as alternative to volatile organic solvents which are toxic and may be hazardous. One of such novel solvent that has been proposed to replace these harmful solvents is the use of deep eutectic solvents (DESs) because of their fascinating properties which have attracted the interest of many researchers since it was proposed in 2003 with a total of about 1,553 scientific publications in this area. Their high solubility property for solutes has envisaged their application as a benign solvent for extraction of bioactive substances in plants. In this overview, we have summarized the recent research progress of DES in its application as a solvent in the extraction of bioactive compounds from plants with the view to advance the concept of using non-toxic solvent in extraction processes.