Purpose of the present study was to carry out extraction, isolation and identification of phytochemical constituents present in leaves extracts of Abutilon pannosum and Grewia tenax collected from Kachchh region, Gujarat by use of Liquid Chromatography Quadrupole Time of Fight Mass Spectrometry (Q-TOF LC/MS). Successive extraction of plant leaves was undertaken by Soxhlet extractor using petroleum ether (35-60°C) as a solvent. Crude petroleum ether extracts were injected in Q-TOF LC/MS instrument for isolation and identification of useful phytochemicals. The result of phytochemical analyses showed that there are very important phytochemicals found in petroleum ether extracts of A. pannosum leaves like Alkaloids, fatty acids, sterol lipid, heterocyclic compound and G. tenax leaves have Fatty acid, alkaloid, flavonoid, terpenoid, sterol lipid and heterocyclic compound, cannabinoid, carotenoid etc and other medicinal activity. Thus, petroleum ether extract of G. tenax leaf gives good medicinal activity compared to the petroleum ether of A. pannosum leaf part. In this study, the G. tenax petroleum ether extract have greatest number of bioactive compounds.