Plant extracts usually occur as a combination of various types of bioactive compounds or phytochemicals with different polarities. The present study investigates the qualitative and quantitative analysis of the major bioactive constituents of medicinally important plant Abutilon pannosum (A.P) and Grewia tenax (G.T) in its dichloromethane (DCM) extract of leaves by use of Liquid Chromatography Quadrupole Time of Fight Mass Spectrometry (Q-TOF LC/MS). Soxhlet extraction of sample was undertaken by continuous hot percolation method using DCM as a solvent. After extraction it was concentrated by use of distillation method. Crude DCM extracts were inserted in Quadrupole-time-offlight (Q-TOF) LC/MS instrument for isolation and identification of valuable phytochemicals. The result of phytochemical investigates exhibited that there are very significant phytochemicals found in DCM extracts of A. pannosum leaves like alkaloids, sterol lipids, glycerophospholipids, fatty acid, steroid glycoside, antioxidant, and heterocyclics compounds and G. tenax leaves have alkaloids, sterol lipids, glycerophospholipids, fatty ester, fatty acid, glycoside, carotene, steroidal alkaloid, triterpene glycosides, glycerophosphates, sesquiterpenes, phosphatidylglycerol, antioxidant, antibacterial, antifungal, antiviralactivity and other biological function. Thus, DCM extract of G. tenax leaves gives decent medicinal activity compared to the DCM extract of A. pannosum leaves part. In this study, the G. tenax DCM extract have greatest number of bioactive compounds. This paper mainly deals with the extraction of active compounds from the leaves part of two plants by used of DCM solvent and investigation of the phytochemicals in DCM extract by used of Q-TOF LC/MS.