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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-3 Issue-9, 2016, Page No: 29-36
Synthesis and Biological Activities Evaluation of New Spiro
Heterocycles Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties
Hany M. Dalloula*, Khaled A. El-nwairyb,Ali Z. Shorafab,Ahmed S. AbuSamahac
a.Department of Chemistry, Faculty of Applied Science, Alaqsa University of Gaza, Palestine.
b.Ministry of Education & Higher Education, Beirut street, Southern Remal, Palestine.
c.Department of Biology, Faculty of Applied Science, Alaqsa University of Gaza, Palestine
b.Ministry of Education & Higher Education, Beirut street, Southern Remal, Palestine.
c.Department of Biology, Faculty of Applied Science, Alaqsa University of Gaza, Palestine
Citation : Hany M. Dalloul, Khaled A. El-nwairy, Ali Z. Shorafa, Ahmed S. AbuSamaha, Synthesis and Biological Activities Evaluation of New Spiro
Heterocycles Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties International Journal of Advanced Research in Chemical Science. 2016;3(9):29-36.
Abstract
A newseries of novel substituted 1,2,4,8-tetraazaspiro[4.5]dec-2-enes have been synthesized from the reaction of 4-piperidone oximes having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectroscopical data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method.Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.
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