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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-3 Issue-7, 2016, Page No: 8-15
Visible Spectrophotometric Method for the Determination of Pharmaceutically Important Aromatic Primary Amines by using P-N, N-Dimethylphenylenediamine and Iodine
M.Srinivasulu1,Elisha Divakar .Tella2*
1.Research scholar PG department of chemistry, Noble college, Machilipatnam
2.Reader & Head, Department of Chemistry, Noble College (Autonomous), Machilipatnam, A.P. India.
2.Reader & Head, Department of Chemistry, Noble College (Autonomous), Machilipatnam, A.P. India.
Citation : M.Srinivasulu, Elisha Divakar .Tella, Visible Spectrophotometric Method for the Determination of Pharmaceutically Important Aromatic Primary Amines by using P-N, N-Dimethylphenylenediamine and Iodine International Journal of Advanced Research in Chemical Science. 2016;3(7):8-15.
Abstract
p-N, N-dimethylphenylenediamine (DMPD) is oxidized with Iodine into p-N, N- dimehyl benzo qui none monoimine which can form a purple –red charge –transfer complex with aromatic primary amine (APA) at pH3.0. The absorbance of the p-N, N-dimehylbenzoquinonemonoimine – APA charge-transfer complex is mea sured at 520nm. This proposed method is simple, rapid and sensitive with reasonable precision and accuracy. The precision of the method was found by analyzing a set of eight solutions, each containing a final concentration value approximately in the middle of the Beer’s law range. The percent relative standard deviation in this method is presented in table-1. The accuracy of the method was determined by taking different known amounts (with in Beer’s law limits) of the drug and analyzing them by proposed method. The results are given in table-2. In the determination of APA the excipients usually present in formulations did not interfere.
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