Department of Applied Chemistry and Chemical Technology, Islamic University, Kushtia-7003, Bangladesh
Abstract
The research work was involved in rapid and efficient procedure for the attachment of barbituric acid with arylidene acetophenone under microwave irradiation (MWI) and conventional heating. The result showed that the time was reduced from the conventional 24 hours to 5-10 minutes. In conventional heating, the yield of the compounds 2
a-2
e were very poor (77-81%), but in MWI methods the yields were observed 96-98% which was comparatively too high. The structures of the compounds were characterized by FT-IR,
1H-NMR spectral data. The antimicrobial and cytotoxic activities of the synthesized compounds were also investigated. All the tested bacteria revealed the zone of inhibition were 6-13 mm where sample concentration was 100 μg disc
-1. However, cytotoxic analysis, the mortality 49-95% were appeared when sample concentration were 0.78-25 (μg ml
-1) and more than 50 μg ml
-1 concentration showed 100% mortality. The presence of a reactive and unsaturated ketone function in synthesized compounds was found to be responsible for their potential antimicrobial and cytotoxic activity.