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  DOI Prefix   10.20431


 

International Journal of Advanced Research in Chemical Science
Volume-3 Issue-6, 2016, Page No: 21-26
DOI: http://dx.doi.org/10.20431/2349-0403.0306004

Synthesis of Bioactive Barbituric Acid Derivatives using Microwave Irradiation Method

Mst. Khodeza Khatun1*,Sharif M. Al-Reza1, M. A. Sattar1

Department of Applied Chemistry and Chemical Technology, Islamic University, Kushtia-7003, Bangladesh


Citation : Mst. Khodeza Khatun, Sharif M. Al-Reza, M. A. Sattar, Synthesis of Bioactive Barbituric Acid Derivatives using Microwave Irradiation Method International Journal of Advanced Research in Chemical Science. 2016;3(6):21-26.

Abstract


The research work was involved in rapid and efficient procedure for the attachment of barbituric acid with arylidene acetophenone under microwave irradiation (MWI) and conventional heating. The result showed that the time was reduced from the conventional 24 hours to 5-10 minutes. In conventional heating, the yield of the compounds 2a-2e were very poor (77-81%), but in MWI methods the yields were observed 96-98% which was comparatively too high. The structures of the compounds were characterized by FT-IR, 1H-NMR spectral data. The antimicrobial and cytotoxic activities of the synthesized compounds were also investigated. All the tested bacteria revealed the zone of inhibition were 6-13 mm where sample concentration was 100 μg disc-1. However, cytotoxic analysis, the mortality 49-95% were appeared when sample concentration were 0.78-25 (μg ml-1) and more than 50 μg ml-1 concentration showed 100% mortality. The presence of a reactive and unsaturated ketone function in synthesized compounds was found to be responsible for their potential antimicrobial and cytotoxic activity.


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