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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-8, 2015, Page No:24-37
Microwave Assisted Synthesis of S-Glycosides Containing 1,5–Benzodiazepines
A.G.M.Haldar,V.N.Ingle,S.S.Chhajed
1.Department of Applied Chemistry , Priyadarshini Bhagwati College of Engineering, R.T.M. Nagpur University, Nagpur, Maharashtra, India
2.Organic Research Lab-1, Department of Chemistry, R.T.M. Nagpur University, Nagpur Maharashtra, India
3.Department of pharmaceutical Chemistry S.S.D.J. College of Pharmacy, Chandwad Maharashtra, India
2.Organic Research Lab-1, Department of Chemistry, R.T.M. Nagpur University, Nagpur Maharashtra, India
3.Department of pharmaceutical Chemistry S.S.D.J. College of Pharmacy, Chandwad Maharashtra, India
Citation : A.G.M.Haldar,V.N.Ingle,S.S.Chhajed, Microwave Assisted Synthesis of S-Glycosides Containing 1,5–Benzodiazepines International Journal of Advanced Research in Chemical Science. 2015;2(8):24-37.
Abstract
2-(4’-mercapto-3’-nitrophenyl)-4-(aryl/hetero aryl)-1H-1,5-benzodiazepines 2a-j were synthesized by condensation of O-Phenylenediamine with substituted propane1,3-diones using silica as solid support under microwave irradiation. A number of their S-glycosides derivatives 3-4 a-j were synthesized with different α-acetobromo sugars in presence of K2CO3 and acetone under microwave condition. On further deacetylation of peracetate glycosides produce glucosyl-, and galactosyl-, containing 1,5 benzodiazepine derivatives 5-6 a-j. these compounds were evaluated for biological activity.
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