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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-7, 2015, Page No:37-42
Conopeptides in Addiction Disorders Treatment
Patrizia Russo,Alessandra del Bufalo
1.Laboratory of Molecular Epidemiology, IRCCS "San Raffaele Pisana" Rome, Italy
2.Laboratory of Molecular Epidemiology, IRCCS "San Raffaele Pisana" Rome, Italy
2.Laboratory of Molecular Epidemiology, IRCCS "San Raffaele Pisana" Rome, Italy
Citation : Patrizia Russo,Alessandra del Bufalo, Conopeptides in Addiction Disorders Treatment International Journal of Advanced Research in Chemical Science. 2015;2(7):37-42.
Abstract
Marine cone snails produce venoms (Conotoxins: CT) that have attracted interest as leads in drug design. CT are small peptides containing one or more disulfide bonds. α-CT specifically target different isoforms of nicotinic acetylcholine receptors (nAChR). In view of the important role of nAChR in normal and disease physiology such as addiction disorders, specific targeting of the relevant nAChR subtypes is an attractive pharmaceutical strategy. In this review the potential of α-CT against addiction disorders will be referred and discussed.
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