Abstract

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A green, an efficient, smooth and direct approach for the synthesis of amidoalkyl naphthols has been described that employs via three-component one-pot reaction of β-naphthol, aromatic aldehydes and amides catalyzed by water receptive and recyclable carbon-based solid acid catalyst derived from glycerol under solvent free conditions with good to excellent yields. The significant features of this protocol are high yields of the products, short reaction time, eco-friendly benign reaction condition, moderate temperature, easy purification, economical due to absence of solvent, lack of toxicity and more environmentally friendly catalyst. The recovered catalyst was reused for five consecutive times without any significant loss of its activity. Therefore, the present protocol with carbon acid catalyst could be an attractive alternative to existing methods for the synthesis of biologically important amidoalkyl naphthols.

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