Abstract

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The huge number of most important active compounds which includes Flavonoids, Flavones, Flavones glycosides, Chalcones, Chalcones glycosides, Xanthones, Diterpenoids, , Dimeric diterpenes and Sterols have been presented in the various parts of Andrographis Paniculata (Kalmegh) of family Acanthaceae. Though in traditional siddha and ayurvedic systems of medicine and tribal medicine, in India and some other countries, multiple clinical applications like anti-infammatory, antiprolifiratory, antihepatic, antithrombogenic, antisnake venom, antipyretic activities, has been indicated for this plant. The compounds that are present in groups in plants produce adverse side effects like gastric upset, headache, bitter taste, and fatigue. But a very few of them isolated the compounds and tested experimently for the above clinical activity. This gave us an impetus to isolate not only that but also produce silver nanoparticles in terpenoid (Ag-NPsTAP) for A.Paniculata and tested for anticancer activity. The anticancer activity of TAP Ag-NPs have been examined over human pathogens such as HeLa, Hep-2 and were examined in different concentrations by MTT assay method. The TAP Ag-NPs showed a maximum activity against HeLa (Human cervical cancer cells) and Hep-2 (Human liver cancer cells) and it was detected to be 59.01% and 48.79% at 250μg/ml respectively. The synthesized Ag-NPs can be used for various applications due to its eco-friendliness, non-toxic and compact ability for pharmaceutical and other applications.

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