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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-12, 2015, Page No:36-41
Synthesis and Evaluation of Antimicrobial Activities of Some New Pyrazoline Derivatives
Jagadeesh Prasad D1*, Laxmana K2, B. Shivarama Holla3, N. Suchetha Kumari4 and Kumara Chaluvaiah5
1.Department of P. G. Studies and Research in Chemistry, Mangalore University,Mangalagangotri, Karnataka, India-574199
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
Citation : Jagadeesh Prasad D,et.al, Synthesis and Evaluation of Antimicrobial Activities of Some New Pyrazoline Derivatives International Journal of Advanced Research in Chemical Science. 2015;2(12):36-41.
Abstract
A series of N-formyl pyrazolines (4a-l) were prepared by treating 1,3-diarylpropenones(3a-l)with hydrazine hydrate and acetic acid at reflux condition. 1,3-diarylpropenones (3a-k) were obtained by treating 4-methylthio benzaldehyde and arylketone in the presence of 10% NaOH and ethanol. The structures of newly synthesized compounds are characterized by elemental analysis, FT-IR, 1H-NMR and mass spectroscopic studies and screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.
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