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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-2 Issue-12, 2015, Page No:7-14
Synthesis and Antimicrobial Evaluation of Some New Mannich Bases Bearing 1,3,4-Oxadiazoline Ring System
Jagadeesh Prasad D1*. Shivarama Holla2 Nalilu.Suchetha Kumari3, Laxmana K4,Kumara Chaluvaiah5
1.Department of P. G. Studies & Research, Chemistry, Mangalore University, Mangalagangotri Karnataka, India-574199
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
2.Department of P. G. Studies and Research in Chemistry, S.D.M College, Ujire , Dakshina Kannada, Karnataka, India-574199
3.Dept of Biochemistry, K. S. Hegde Medical Academy, Deralakatte-574162, India 4.Department of Chemistry, University College, Dakshina Kannada, Kranataka, India
Citation : Jagadeesh Prasad D,et.al, Synthesis and Antimicrobial Evaluation of Some New Mannich Bases Bearing 1,3,4-Oxadiazoline Ring System International Journal of Advanced Research in Chemical Science. 2015;2(12):7-14.
Abstract
A Series of 3-[(phenylamino)methyl]-5-(2,3,4-trichlorophenyl)-1,3,4-oxadiazole-2(3H)-thione (6a-l) and 3-[(alkylamino)methyl]-5-(2,3,4-trichlorophenyl)-1,3,4-oxadiazole-2(3H)-thione (7a-l) (Scheme 3) were synthesized by treating 1,3,4-oxadiazol-2-thione(5) with primary/secondary amines and formaldehyde. 1,3,4-oxadiazol-2-thione(5) (Scheme 2) was prepared by refluxing hydrazide with carbon disulfide and KOH in ethanol. 2,3,4-trichlorophenyl Hydrazide (Scheme 1) was synthesized from 2,3,4-trichloroacetophenone using the procedure reported in literature. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H-NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.
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