Synthesis, Characterization and Antibacterial Activity of Imidazole Derivatives of 1,10-Phenanthroline and their Complexes

Dr. Kabeer A Shaik; Azeem Ahmed

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International Journal of Advanced Research in Chemical Science

Volume-1 Issue-8, 2014, Page No:40-44

Synthesis, Characterization and Antibacterial Activity of Imidazole Derivatives of 1,10-Phenanthroline and their Complexes

Dr. Kabeer A Shaik¹, Azeem Ahmed²

1.Organic Synthesis Laboratory, P.G. Department of Chemistry, Sir Sayyed College of Arts,Commerce and Science,Aurangabad,India
2.Organic Laboratory, MVS Government Degree and P.G. College, Mahabubnagar, India

Citation : Dr.Kabeer A Shaik,Azeem Ahmed, Synthesis, Characterization and Antibacterial Activity of Imidazole Derivatives of 1,10-Phenanthroline and their Complexes International Journal of Advanced Research in Chemical Science. 2014;1(8):40-44.

Abstract

Thirty Five new MnL¹,CuL¹,CoL¹,NiL¹,CrL¹,FeL¹ and ZnL¹(L¹=4-methyl(1H-imidazo[5,6-f][1,10]phenanthroline)-2-yl)phenol),MnL²,CuL²,CoL²,NiL²,CrL²,FeL² and ZnL² (L² = 2-(1H-imidazo[4,5-f] [1,10]phenanthroline-2-yl)-5-methoxyphenol), MnL³,CuL³,CoL³,NiL³,CrL³,FeL³ and ZnL³ (L³⁴,CuL⁴,CoL⁴,NiL⁴,CrL⁴,FeL⁴ and ZnL⁴ (L⁴=4-Fluro Imidazo[5,6-f] 1,10-phenanthroline, MnL⁵,CuL⁵,CoL⁵,NiL⁵,CrL⁵,FeL⁵ and ZnL⁵ (L⁵=[4-Hydroxy phenyl]Imidazo [5,6-f]1,10-phenanthroline complexes were synthesized. L¹, L²,L³,L⁴ and L⁵ ligands were prepared by the condensation of 1,10-phenanthroline-5,6-dione with 2-hydroxy-4-methoxybenzaldehyde, paramethyl benzaldehyde ,2,4,6-Trimethoxy Benzaldehyde,4-Fluro Benzaldehyde,4-Hydroxy Benzaldehyde respectively. The structures of the compounds were determined by elemental analyses, IR,UV-visible and 1H-NMR. Antibacterial activity of the ligands and their metal complexes were tested against selected bacteria by disc diffusion method.

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