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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-1 Issue-2, 2014, Page No:11-20
Eco-friendlyand Efficient Synthesis, Characterization and Anti-Bacterial Activity of Schiff Base Ligandsand their Copper (II) Complexes
K.P.Srivastava, Anuradha Singh & Suresh Kumar Singh
Department of Chemistry, Ganga Singh College, J.P.University, Chapra, Bihar, INDIA
Citation : K.P.Srivastava, Anuradha Singh & Suresh Kumar Singh, Eco-friendlyand Efficient Synthesis, Characterization and Anti-Bacterial Activity of Schiff Base Ligandsand their Copper (II) Complexes International Journal of Advanced Research in Chemical Science. 2014;1(2):11-20.
Abstract
Microwave irradiation as a green approach for rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Cu(II) have been developed using condensation of pyridoxal and amoxicillin (L1), cephalexin (L2), sulphamethoxazole (L3) and trimethoprim (L4) efficiently in analcoholic suspension medium using alkali catalyst with excellent yields. This method provides several advantages such as environmental friendliness, simple work-up procedure, short reaction times, non-hazardous and excellent yield of products.The results are compared with conventional methods for their yield and reaction time. The Schiff base ligands and the complexes were characterized by micro-analytical, thermo-gravimetric, magnetic and spectroscopic studies.All the Schiff bases were bidentate (NO donor) ligands. All complexes were found to be six co-ordinate dihydrates and ML2[1:2 (metal: ligand) ratio] type. The complexes are coloured and stable in air. All the complexes under investigation possess antibacterial activity. The antibacterial activity showed the following trend: Cu (II)-complexes ˃ Schiff base ligands ˃ parent drugs.
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