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DOI Prefix 10.20431 |
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International Journal of Advanced Research in Chemical Science
Volume-1 Issue-1, 2014, Page No:1-9
Immunohistochemical Detection of Bcl-2 Protein in Normal and Abnormal Rat Liver
Amany Nofal1, Andrei Potaрov2, Andrei Khlebnikov2
1.I. Polzunov Altai State Technical University, Barnaul, Russia
2.Zoology department, Faculty of science, Menoufia University, Egypt
2.Zoology department, Faculty of science, Menoufia University, Egypt
Citation : Amany Nofal, Andrei Potaрov, Andrei Khlebnikov, Immunohistochemical Detection of Bcl-2 Protein in Normal and Abnormal Rat Liver International Journal of Advanced Research in Chemical Science. 2014;1(1):1-9.
Abstract
Animals treated with 1,5-Bis(3,5-Dimethylpyrazol-1-yl)-3-oxapentane-diacetatocopper for 2, 4 and 6 weeks in the present study revealed many histopathological and immunohistochemical observations in the liver. Examination of liver sections after experimental periods of treatment manifested loss of normal hepatic structure; inflammatory infiltration, marked enlarged vacuolated cytoplasm in cells, congestion of blood vessels, as well as, some of the degenerated cells showed karyorhexis, pyknosis and area of necrosis. the present study revealed negative expression of Bcl-2 proteins in all hepatic cells of control rats and positive expression of Bcl-2 proteins in hepatic cells of treated rats with 1,5-Bis(3,5-Dimethylpyrazol-1-yl)-3-oxapentane-diacetatocopper.
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