The Impact of Smoking on Urologic Outcomes
Tom Feng1, Devin Patel1, Dhruv Khullar2, Mark Vogel1, John Maa3
Copyright : © 2016 Maa J. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
1.Introduction
2.Methods
3.Result
Most tobacco products are made from the species Nicotiana tabacum, which contains approximately 4,000 chemical compounds, at least 55 of which are carcinogenic. Cigarette smoke has a number of toxic effects, including impaired immune function, free radical release, cellular damage, and thrombogenesis [4]. These combined effects on the microvasculature are exacerbated by carbon monoxide, and result in the detrimental delivery of essential oxygen, nutrients, growth factors and immune cells thereby contributing to tissue hypoxia and delayed wound healing. Tobacco also stimulates a stress response mediated by enhanced fibroblast activity resulting in decreased cell migration and increased cell adhesion [4]. This results in is inappropriate connective tissue deposition at the surgical site and delayed wound healing.
Bladder cancer is the second most common malignancy of the genitourinary system, and also the second most common tobacco-related malignancy following lung cancer. Cigarette smoking has been repeatedly shown to be the leading cause of bladder cancer. Cigarette smoke contains many known bladder carcinogens including B-naphthylamine, polycystic aromatic hydrocarbons, and other aromatic amines [4]. These substances are renally excreted, concentrate within the bladder, and directly affect the urothelial tissue. In addition to the mechanisms described earlier, the carcinogens in tobacco exert an oncogenic effect by inducing p53 mutations, rendering chromosomal abnormalities, and suppressing immune function The high prevalence of smoking among patients undergoing surgery for bladder cancer has resulted in numerous studies investigating the role of smoking in carcinogenesis, cancer progression, postoperative complications, and treatment response. Recent studies indicate that the population- attributable risk of bladder cancer for tobacco smoking as 50% in men and 52% in women[5]. Current smoking increases the risk of developing bladder cancer by as much as fourfold [5]. The intensity and duration of smoking also confers increased risk of cancer, whereas smoking cessation reduces but does not eliminate this risk [6]. The immediate decrease in risk of bladder cancer was 30% after 1-4 years of abstinence and over 60% after 25 years [6]. A case comparison study of over 1000 patients with bladder cancer showed that current smokers were four years younger, and had larger and higher T stage tumors compared with never smokers. In addition, muscle invasive disease was more prevalent in current and former smokers compared to nonsmokers [7]. Furthermore, patients with a heavy smoking history are more likely to have clinically advanced disease at presentation.
One study investigating robotic cystectomy showed smoking as a risk factor for the development of high grade complications, defined as those requiring invasive management, repeat surgery or resulting in lasting disability [8]. In both superficial and invasive disease, smoking intensity and duration shows a dose-responsive negative effect on tumor stage, regional metastasis and disease recurrence after surgery [9, 10].
Following surgical treatment for bladder cancer, patients diagnosed at earlier stages are more likely to continue smoking; however, continued and prolonged smoking exposure is negatively associated with disease progression [9, 11]. Smoking also negatively impacts postoperative adjuvant bladder cancer treatments. During chemotherapy, smoking can exacerbate drug side effects, further impair immune function, increase the incidence of infection, exacerbate treatment related cachexia, and induce hepatic enzymes to alter metabolism rates [12]. Smoking is a risk factor for cisplatin nephrotoxicity [13]. Smokers are more likely to both fail initial Bacillus Calmette Guerin (BCG) therapy, and recur after treatment [9].
Cigarette smoking has now been established by the US Surgeon General as an established causal risk- factor for developing renal cell cancer. A review of the various environmental risk factors revealed that the strongest association is between smoking and the development of kidney cancers involving the renal parenchyma and renal pelvis/ureter [14]. Studies have shown a clear dose-response correlation, and an observed benefit of smoking cessation on risk reduction. A multicenter, population based case control study of over 1,730 smokers and 2,300 control patients showed that current smokers have a 40% increase in risk in renal cell carcinoma (RR= 1.4) [15]. The risk also increased with number of cigarettes smoked and duration of smoking. Furthermore, former smokers who abstained from smoking for more than 15 years experienced a reduction in risk of about 15-25% relative to current smokers.
Smoking also affects outcomes related to cancer specific mortality. Smokers were found to have more aggressive disease and more advanced tumors at presentation. Smoking was associated significantly with tumor multifocality, higher pathologic tumor classification, an increased risk of bulky lymph node disease, and the presence of distant metastasis [16]. The study also showed a poorer cancer- specific survival after nephrectomy for smokers [16].
Furthermore, smoking is a renal toxin, predisposing to postoperative acute kidney injury (AKI) and chronic renal failure (CRF). Studies show that chronic nicotine exposure leads to up-regulation of renal oxidative stress pathways with exacerbation of ischemia-reperfusion induced free-radical generation and AKI [17]. Indeed, studies show that the incidence of AKI is higher among smokers following radical nephrectomy with thrombectomy, major vascular surgery, and intravenous contrast exposure[18]. After radical or partial nephrectomy, smoking is a risk factor for developing CRF. Following RCC surgery, smoking cessation may be equally important as surgical technique in preserving long-term glomerular function, as a serum creatinine rising above 2.0 mg/dL was more common in smokers compared to non-smokers (OR 5.29; 95% CI 2.58–10.87). This increased risk for a serum creatinine rise is similar for smokers over non-smokers as compared to those undergoing radical nephrectomy over renal sparing surgery (OR 3.08; 95% CI 1.64–5.78)[19].
In addition, smoking may adversely affect medical treatment of metastatic renal cell carcinoma. One study showed that active smoking negatively affected the progression free survival and overall survival of patients with metastatic RCC undergoing treatment with sunitinib [20]. Smokers are at higher risk of having abnormal baseline pulmonary function tests, thereby potentially excluding them from IL-2 therapy. Thus, the benefit of smoking cessation in kidney cancer therapy extends beyond reducing cancer risk and progression, but also to extending the effectiveness of adjuvant treatment.
The established risk factors for prostate cancer include increasing age, African American ethnicity, and positive family history. Only recently has smoking been linked to increased prostate cancer risk. Plaskon et al compared 753 male smokers ages 40-64 diagnosed with prostate cancer with age- matched controls, and demonstrated current smokers to have an increased risk (OR = 1.4) relative to nonsmokers [21]. A dose-response relationship was also noted between duration of smoking and prostate cancer risk and aggressiveness of disease. An earlier age at which men first started smoking was also a strong risk factor for aggressive disease.
A proposed mechanism of tobacco in prostate cancer genesis and progression include the increased exposure to carcinogenic compounds in cigarettes, such as polycyclic aromatic hydrocarbons, heterocyclic aromatic amines, nitrosamines, and cadmium [22]. Smoking is also associated with an increase in bioavailable serum androgens and decrease in estradiol [23]. Testosterone and its potent metabolite DHT are necessary for normal prostate cell development and proliferation and conversely, estrogens act on the hypothalamus pituitary axis to suppress androgen production. Thus the changes in hormone levels associated with smoking may contribute to the development and progression of prostate cancer.
Smoking is associated with adverse pathologic features and a higher risk of biochemical recurrence in men undergoing radical prostatectomy. Among patients undergoing radical prostatectomy, cigarette smoking was associated with an increased risk of metastasis and higher risk of biochemical recurrence, castrate resistant prostate cancer, and overall mortality [24]. Smoking also negatively impacts patients undergoing curative external beam radiation therapy for localized disease. Pickles et al demonstrated that current smokers presented with higher risk cancers, and smoking was an independent risk factor for poorer outcome following radiation therapy [25]. In addition, smoking adversely impacts erectile function recovery after radical prostatectomy [26]. Smoking was the strongest predictor of bladder neck contracture when compared to coronary artery disease, hypertension, and diabetes [26]. Smoking has also been associated with a negative impact upon erectile function after external beam pelvic irradiation for prostate cancer. Goldstein et al showed a higher incidence of smoking in men who lost potency after radiation therapy [27].
Unlike the other urological malignancies, the link between testicular cancer and smoking is less clearly defined. The UK Testicular Cancer Study Group evaluated smoking exposure in a case-control study of 794 men with testicular cancer and did not find a significantly increased risk with cigarette smoking [28]. In contrast, a recent study from Canada did demonstrate an increased risk of testicular cancer in men with greater than 12 pack year history [29]. Of note, however, they did not notice any association with age of initiation of smoking nor reduction of risk with smoking cessation. Further studies are needed to definitely delineate the effect of smoking and testicular cancer.
There is stronger evidence that smoking impacts outcomes after testicular cancer surgery and adjuvant treatment. Smoking-induced free radical damage and vascular injury increase the risk of bleomycin- induced pulmonary toxicity and Raynaud’s phenomenon after adjuvant therapy for testicular cancer [30]. The rates of major complications in testicular cancer survivors, including secondary malignancy, early cardiovascular disease, depression, anxiety and sexual function inventory scores are all negatively affected by smoking [31, 32]. The effect of smoking on fertility following orchiectomy has not been studied directly, but smoking alters seminal fluid to introduce free radicals, deplete antioxidants and increase leukocyte content [33]. This contributes to increased oxidative species, which are known to harm sperm during cryopreservation.
The evidence for the effect of smoking on male fertility is evolving. Current evidence shows a negative influence that begins before birth, continues into adulthood, and alters assisted-reproductive outcomes. In utero smoke exposure is associated with higher risk for bilateral cryptorchidism and reduced adult sperm quality, count and testicular size [34]. Adult male smokers have decreased semen volume, sperm number and percentage of motile forms [33]. Sperm samples from smokers in both general and infertility clinic populations have shown higher genetic damage, abnormal morphology, altered meiosis and reduced acrosin activity [35]. Among male smokers, these effects translate into a three-fold higher rate of treatment failure with both in vitro fertilization and intra-cytoplasmic sperm injection [36].
Smoking compounds the effect of a varicocele on infertility and may impact treatment response. Among patients with a varicocele, the incidence of oligospermia is tenfold higher in smokers. A study of infertile patients with varicoceles found that seminal cadmium levels rose with smoke exposure, and predicted testicular atrophy and poor response to varicocelectomy [37]. Smoking cessation should be universally recommended in patients presenting with infertility. In addition to reducing maternal second-hand exposure, tobacco abstinence for as little as 3 months results in improved semen parameters [38].
Independent of other factors, there is a 30% higher risk for erectile dysfunction (ED) with each 10 pack-years smoked [1, 39]. Unlike other risk factors for ED, the magnitude of the association between smoking and ED decreases with older age, suggesting a stronger relationship in young male smokers [39]. Smoking-induced arterial atherosclerosis is the main culprit in the higher prevalence of early onset ED, and a poorer response to treatment [40]. Tobacco-mediated hypoxia induces fibrosis and resultant venous leakage, a condition associated with high treatment refractoriness [40]. Smoking directly impairs the main mechanisms that maintain cavernosal health, endothelial nitric oxide synthase, VEGF signaling and tissue oxygen pressure [41]. Because of these changes, active smoking is a risk factor for poor response to phosphodiesterase-5 inhibitors [42]. Following intracavernous PgE1 injection, male smokers, independent of baseline potency and co-existing arterial disease, show worse erectile response and reduced flow parameters when compared to non-smoking counterparts [43]. Smoking cessation, even with nicotine replacement, can significantly enhance physiological and self-reported indices of sexual health in long-term male smokers [44].
Cigarette smoking has also been implicated as a risk factor for forming calcium urolithiasis [45]. In fact, smoking may be a stronger risk factor of calcium oxalate stone formation than hypertension, hypercholesterolemia, or BMI [46]. Scott et al also demonstrated that increased serum cadmium levels, a known toxin of cigarettes, may be a risk factor for urinary tract stone formation as 40% of the group with high cadmium levels had kidney stones compared to 3.5% in the general population [47]. Furthermore, smoking seems to also confer a negative impact on spontaneous passage of some kidney stones. Though total stone passage rates were similar in smoking and nonsmoking groups, the passage rate in patients with stone diameters greater than 4 mm was lower in smokers [48].
Lower urinary tract symptoms (LUTS) represent a common urological complaint. This collection of urinary symptoms often present in older men with benign prostatic hyperplasia but may be seen in other urological disorders. One study showed a positive correlation with smoking and prevalence of lower urinary tract symptoms, and also emphasized the importance of smoking cessation as the risk of LUTS was decreased with long term abstinence [49]. Other studies have demonstrated a positive association between smoking and symptoms such as urgency, nocturia, and female urinary incontinence [50]. The incidence of female stress incontinence is higher in current smokers than former smokers, and the intensity and duration of cigarette consumption are associated with higher risk for stress incontinence [51].
Smoking also appears to negatively impact outcomes of surgeries related to LUTS. Current smoking status has been shown as a risk factor for mesh erosion for those undergoing vaginal sling procedures for urinary incontinence [52]. Former and current smoking status has been shown to increase morbidity after transurethral resection of the prostate for BPH, by increasing the risk of large scale fluid absorption (greater than 1L) with former and current smoking status [53]. The outcome following urethroplasty in smokers is poor, and includes a high rate of stricture reformation [54].
The kidney is susceptible to the pathogenic effects of tobacco use. Recent data from experimental studies indicate that smoking is a risk factor for renal function deterioration. One study demonstrated a 4.3 fold greater rate of GFR decline observed in active vs nonactive smokers. The rate of GFR decline was also independently associated with heavy smoking [55]. Another study showed that second-hand smoking was independently associated with nephrotic range proteinuria and thus plays a role in chronic kidney disease progression [56].
The effects of smoking on kidney transplantation have been studied extensively. Smoking, both by donors and by recipients, has a negative effect on transplant outcomes including an increased risk of allograft loss and death [57] resulting from fibrous intimal thickening of small arteries. Patients who were smokers at the time of pretransplant evaluation had kidney graft survival of 84%, 65%, and 48% at 1, 5, and 10 years, respectively, compared with graft survival in nonsmokers of 88%, 78%, and 62% [58]. They also reported that 90% of recipients who were smokers continued to smoke. For those who quit prior to receiving a transplant, graft survival was higher. In addition, smoking by kidney donors also negatively affects donor and recipient renal function following living donor nephrectomy [59]. Donors who actively smoke or have a past history of tobacco use have a larger percent increase in creatinine at one year following donation compared to donors who have never smoked. Recipients of smoker’s organs are also at a greater risk of extended intensive care stays and greater need for ventilation. Furthermore, smoking by kidney transplant recipients significantly increases the risk of cardiovascular events, renal fibrosis, rejection, and malignancy [60].
The public has a low overall awareness of smoking’s impact on urological conditions. Only 33.5%, 25.2% and 24.2% of patients identified smoking as a risk factor for kidney cancer, bladder cancer, and erectile dysfunction, respectively, compared to 94.0% who identified it as a risk factor for lung cancer. This lack of awareness is most pronounced in ethnic minorities and current smokers. Hispanic and black patients were 2 to 3 times more likely than white patients, and smokers were twice as likely as nonsmokers, to be unaware of the association of smoking with kidney and bladder cancer [61].
A “teachable moment” is an event such as disease diagnosis or hospitalization that motivates a patient to change a risky health behavior, when they are particularly concerned about their health. The scheduling of elective surgery after the diagnosis of bladder cancer presents a powerful opportunity for urologists to encourage smoking cessation, as one study showed that smokers newly diagnosed with bladder cancer were almost five times more likely to quit than smokers in the general population. These patients cited their new diagnosis and the advice from urologists as the key reasons for cessation [62] Preoperative smoking cessation not only decrease perioperative morbidity, but also promotes permanent smoking cessation to enable the patient to benefit from a tobacco-free life longterm.
Despite the potential “teachable moment” that surgery presents for smoking cessation, urologists are currently not capitalizing on this opportunity (Table 3). More than half of urologists never discuss smoking cessation, and only one-fifth discuss smoking cessation with patients with bladder cancer, the malignancy with the strongest association with smoking [62]. Perhaps the current thinking of urologists needs to be reframed to promote the awareness of smoking and its association with urological diseases. Of urologists who never discuss smoking cessation, 40.7% believe that smoking cessation may not change the outcome of the disease, and 37.7% do not feel qualified to provide counseling [62]. Additionally, most urologists (93.7%) have never had formal smoking cessation training [62]. Urologists who had some form of cessation training were more likely to provide counseling compared to those without training [62].
Effective interventions that urologists can utilize to help patients to stop smoking include simple open dialog about the patient's motivation to quit, individual counseling, group counseling, and repeated personal contact. A novel smoking warning label to raise awareness of the deleterious effects of smoking on bladder cancer was shown to a cohort of 291 patients at urology and family practice clinics: 58.1% stated that it had changed their opinion on smoking and bladder cancer and 74.8% felt that this label would raise awareness of the hazards [63]. Moving beyond raising awareness are investigations of smoking cessation interventions. One study compared patients who were enrolled in either 1) a brief 5 minute smoking cessation intervention, 2) intervention plus nicotine replacement therapy, or 3) a control group [64]. They demonstrated the one year quit rate in the intervention group was 12.1% vs 2.6% in controls. The addition of nicotine replacement therapy increased the quit rate to 19.5%. Patients enrolled in the brief smoking cessation intervention were also more willing to attempt to quit. This study demonstrates how urologists can successfully implement a smoking cessation program.
Finally, newer urine markers are being developed to help clinicians validate abstinence. Urinary nicotine levels will be elevated in both active smokers and those on nicotine replacement therapy. Urine concentration of the tobacco alkaloids anabasine and anatabine have been demonstrated to be
useful biomarkers to distinguish active tobacco use from patients on nicotine replacement therapy [65]. With these new markers, clinicians can individualize counseling with their patients who are in cessation programs, and monitor patient compliance and success.
4.Discussion
5.Conclusion
6.Acknowledgements
References