This work was directed to evaluate the in vitro anti-arthritic activity of extracts in water, ethanol and diethylether of the rhizomes from Anredera vesicaria. Solutions at 125, 250 and 500 µg/mL from the dry extract of the rhizomes were prepared, these solution were subjected to evaluation of the anti-arthritic activity in vitro by the method of inhibition of protein denaturation. According with the obtained results all the products are able to inhibit the denaturation of proteins, therefore, they present anti-arthritic activity, there being significant differences among the tested products. All the extracts evaluated showed anti-arthritic activity. The greatest activities were presented by the ethanol extracts.