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  DOI Prefix   10.20431


 

ARC Journal of Pharmaceutical Sciences
Volume 4, Issue 3, 2018, Page No: 13-20

Formulation and Evaluation of Immediate Release Tablets of Nevirapine Solid Dispersions

Prasanna Kumar Desu1*, P. Venkateswara Rao1, T. Prasanthi1, G. Sri Lakshmi1, K.Sai Sankar1, Sk. Muneer1

1.Department of Pharmacy, St. Mary's Group of Institutions Guntur, Chebrolu (V&M), Guntur, Andhra Pradesh, India.

Citation : Prasanna Kumar Desu,et.al, Formulation and Evaluation of Immediate Release Tablets of Nevirapine Solid Dispersions ARC Journal of Pharmaceutical Sciences 2018, 4(3) : 13-20

Abstract

The objective of the present study was to develop immediate release tablets of Nevirapine in order to achieve rapid release in GIT which might result in enhanced absorption and thereby improved bioavailability. Six batches of solid dispersions of Nevirapine were prepared by using different ratios urea and PEG 6000 as Carriers. Drug-excipients interaction was carried out for pure drug and optimized formulations by using FTIR studies. Nevirapine tablets were formulated employing different synthetic polymers fusion dispersions by direct compression method. All the batches of immediate release tablets were evaluated with reference to different pre-compression and post-compression parameters. Based evaluation of different parameters it was concluded that formulation of immediate release tablets of Nevirapine was successfully done and F4 shows 100% at 60 min.


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