The objective of the present study was to evaluate the effect of Trichosanthes Cucumerina in increasing the platelet count. Trichosanthes Cucumerina (Cucurbitaceae) is a traditional medicinal plant known as snake guard. Snake gourd is an annual climber and it's commonly called as snake gourd, viper gourd, snake tomato or long tomato. The fruit is usually consumed as a vegetable due to it is good nutritional value. The fruit is a good source of Vitamin A, Vitamin B and Vitamin C. It improves the appetite and acts as a tonic and stomachic and cures biliousness. This is one of the most genetically diverse groups of food plant in the plant kingdom and every part of this plant is used to treat various diseases. It is used in the treatment of head ache, alopecia, fever, abdominal tumors, bilious, boils, acute colic, diarrhea, hematuria and skin allergy. T. curcumineriais used as an abortifacient, vermifuge, stomachic, refrigerant, purgative, malaria, laxative, hydragogue, hem agglutinant, emetic, cathartic, bronchitis and anthelmintic. study was undertaken to evaluate the possible increasing platelet count effect of Trichosanthes Cucumerinafresh juice extract (TCJE) using Cyclophosphamide induced thrombocytopenia. Group-I (control) received normal saline (1ml/100gm), Group-II receiving Cyclophosphamide (200mg/kg), Group III & IV received Cyclophosphamide and TCJE in doses of 200 mg, 200 & 400 mg/kg orally (P.O.) respectively. Blood samples were collected after 60 minutes of dose administration and TCJE produced significant increase in platelet count like effect at dose of 200 & 400 mg/kg administered for 7 & 14 consecutive days as indicated by increasing blood parameters like Hemoglobin, total leucocytes count, polymorphs, lymphocytes, eosinophils, monocytes, platelet count and red blood cells count of Rat in TST & FST (P< 0.05). The efficacy of ZJPE at 400mg/kg was found to be comparably more.