Acute otitis media (AOM) is a common childhood disease. Treatment of AOM cases has many problems for both patients and physicians, and in some cases recurrences of disease complicates the patient's condition. The aim of this case was to report the treatment of a recurrent AOM case with sequential treatment failures. The patient had a history of 2- year complicated form of chronic and acute otitis media with apparent criteria of approved AOM case. After 5 times of treatment failures by first line antibiotics, a combination of high-dose amoxicillin, silver nanoparticles, and ethanol 70% was prescribed for 7- day. After the mentioned treatment method, clinical condition, and audiometric parameters of patient changed to normal results. Although it seems like immoral, but considering one year follow-up after recovery without AOM recurrency and any other complications, this treatment regime is proposed for further clinical trials by ENTs.