Sacrocephalus latifolius is used in folk medicine for treatment of menstrual pain, stomach disorders; including gastric ulcer. The methanol extract of Sacrocephalus latifolius was evaluated for antiulcer activity in twenty-five Swiss albino rats divided into five groups of five rats per group. Various doses 100,200 and 400 mg/Kg of leaf extracts were administered orally to the animals in groups II -V while Omeprazole (B.P) 20 mg (Standard drug) was used as positive control in group I animals and normal saline 10 mL was used in the negative control group II. Stomach was opened along the greater curvature then; ulceration index was determined by examining the inner lining of stomach. Results showed that the rate of ulceration decreases in area of stomach affected with increased doses. Rats in group V with dose 400 mg/Kg of leaf extract showed the most reduced affected area with 1.2 ± 0.3b and 76 % inhibition of ulceration while group II with dose 10 mL normal saline (negative control) has the highest rate of ulceration of 8.0 ± 0.3b. The study showed that Sacrocephalus latifolius leaf decreased the area of ulceration in the stomach of rats in dose-dependent fashion, thus justifies its used in traditional medicine in the treatment of gastric ulcer.